Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
| ▸ | CCR4 | P51679 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 2/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086725 | 0.79 | CCR4 (0.56) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL7230611 | 0.79 | MEN1 (0.51) | MEN1KMT2ALMNAMAPTFFAR2 | |
| SCHEMBL25883270 | 0.75 | FFAR2 (0.46) | MEN1KMT2ALMNAMAPTFFAR2 | |
| SCHEMBL25083766 | 0.75 | LMNA (0.55) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL3610148 | 0.73 | FFAR2 (0.51) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL6239068 | 0.72 | L3MBTL1 (0.56) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL3697564 | 0.71 | CCR4 (0.38) | MEN1KMT2ALMNAMAPTFFAR2 | |
| SCHEMBL245790 | 0.71 | SMN1; SMN2 (0.44) | MEN1KMT2ALMNAMAPTGFER | |
| SCHEMBL7493305 | 0.71 | KMT2A (0.51) | MEN1KMT2ALMNAMAPTGFER | |
| SCHEMBL29274266 | 0.71 | ALOX5 (0.59) | MEN1KMT2ALMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247819-A2 | METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS | AGIOS PHARMACEUTICALS, INC. (US) | 2020-12-10 | — | — | WO | disclosed |
| EP-1562589-B1 | DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2009-01-07 | — | — | EP | disclosed |
| CN-1738615-A | Diaminotriazoles as inhibitors of protein kinases | VERTEX PHARMA (US) | 2006-02-22 | — | — | CN | disclosed |
| WO-1993003036-A1 | BENZOPYRANO[4,3-c]PYRAZOLES, THEIR PREPARATION AND THEIR USE AS IMMUNOMODULATORS | THE BOOTS COMPANY PLC (GB) | 1993-02-18 | — | — | WO | disclosed |