SCHEMBL6239068

SCHEMBL6239068

CC(=O)Nc1nc(C(F)(F)F)cs1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.56
FFAR2 O15552 1/20 0.53
KMT2A Q03164 4/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
KDM4E B2RXH2 3/20 0.50
HSD17B10 Q99714 2/20 0.50
MAPT P10636 1/20 0.50
ABL1 P00519 4/20 0.48
NPC1 O15118 2/20 0.48
MAPK1 P28482 2/20 0.48
RAB9A P51151 2/20 0.47
POLB P06746 2/20 0.47
ATAD2 Q6PL18 1/20 0.47
LMNA P02545 1/20 0.47
MEN1 O00255 3/20 0.46
ALDH1A1 P00352 1/20 0.46
TAS1R3 Q7RTX0 1/20 0.46
TAS1R1 Q7RTX1 1/20 0.46
TAS1R2 Q8TE23 1/20 0.46
TYR P14679 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3610148 0.84 FFAR2 (0.51) FFAR2KMT2ASMN1; SMN2KDM4EHSD17B10
SCHEMBL2608447 0.84 ATAD2 (0.63) L3MBTL1KMT2ASMN1; SMN2KDM4EHSD17B10
SCHEMBL13015672 0.83 TMIGD3 (0.56) FFAR2KMT2ASMN1; SMN2KDM4EHSD17B10
SCHEMBL9891920 0.82 FFAR2 (0.63) FFAR2KMT2ASMN1; SMN2KDM4EHSD17B10
SCHEMBL23703017 0.80 FFAR2 (0.48) FFAR2KMT2ASMN1; SMN2KDM4EHSD17B10
SCHEMBL25057018 0.79 PIK3CG (0.51) FFAR2KMT2AKDM4EHSD17B10MAPT
SCHEMBL1968036 0.76 NPC1 (0.62) KMT2ASMN1; SMN2KDM4EHSD17B10MAPT
SCHEMBL7230611 0.76 MEN1 (0.51) FFAR2KMT2AMAPTNPC1RAB9A
SCHEMBL13055749 0.75 RAB9A (0.57) KMT2ASMN1; SMN2KDM4EHSD17B10MAPT
SCHEMBL7493305 0.75 KMT2A (0.51) FFAR2KMT2AKDM4EMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 US disclosed
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 US disclosed
CN-116472292-A Modified proteins and protein degrading agents 上海睿跃生物科技有限公司 2023-07-21 CN disclosed
EP-4157888-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS Cullgen (Shanghai), Inc. (CN) 2023-04-05 EP disclosed
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2023-02-23 US disclosed
WO-2021239117-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI) , INC. (CN) 2021-12-02 WO disclosed
US-8629157-B2 Pyrrolidine compounds which modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-01-14 US disclosed
US-8449898-B2 Fungicidal mixtures E I DU PONT DE NEMOURS AND COMPANY (US) 2013-05-28 US disclosed
US-8449898-B2 Fungicidal mixtures E I DU PONT DE NEMOURS AND COMPANY (US) 2013-05-28 US disclosed
EP-2217565-B1 COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR BOEHRINGER INGELHEIM INT (DE) 2013-05-22 EP disclosed
US-20100240619-A1 FUNGICIDAL MIXTURES CORTEVA AGRISCIENCE LLC 2010-09-23 US disclosed
US-20100240619-A1 FUNGICIDAL MIXTURES CORTEVA AGRISCIENCE LLC 2010-09-23 US disclosed
WO-2009055514-A2 FUNGICIDAL MIXTURES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-04-30 WO disclosed
US-20050137239-A1 Thiazole derivatives AVON PRODUCTS, INC. 2005-06-23 US disclosed
EP-1543824-A2 Thiazole derivatives to counter advanced glycation Avon Products, Inc. (US) 2005-06-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050137239-A1 Thiazole derivatives TYR, AGER, AOX1 L3MBTL1 4228/4885FFAR2 2466/4885KMT2A 3443/4885
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 L3MBTL1 707/4885FFAR2 4574/4885KMT2A 1342/4885
US-20100240619-A1 FUNGICIDAL MIXTURES CYP1B1, CYP1A1, NOX1 L3MBTL1 769/4885FFAR2 1176/4885KMT2A 2074/4885
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 L3MBTL1 707/4885FFAR2 4574/4885KMT2A 1342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.