Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046232 | 0.88 | RIPK1 (0.51) | RIPK1GAAHPGDCCNCCDK8 | |
| SCHEMBL4051349 | 0.83 | RIPK1 (0.44) | RIPK1GAAHPGDCCNCCDK8 | |
| SCHEMBL28171621 | 0.83 | RIPK1 (0.67) | RIPK1 | |
| SCHEMBL17142307 | 0.83 | RIPK1 (0.48) | RIPK1GAAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL4046460 | 0.82 | MLYCD (0.44) | RIPK1GAAHPGDCCNCCDK8 | |
| SCHEMBL30878611 | 0.80 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL18406194 | 0.80 | NPC1 (0.59) | RIPK1GAAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL27564986 | 0.80 | RIPK1 (0.62) | RIPK1 | |
| SCHEMBL17142321 | 0.79 | RIPK1 (0.52) | RIPK1GAAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1576663 | 0.79 | RIPK1 (0.73) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103478-A1 | PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |