Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | CFB | P00751 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046089 | 0.82 | RIPK1 (0.50) | RIPK1ROCK2CCNCCDK8GAA | |
| SCHEMBL4046232 | 0.80 | RIPK1 (0.51) | RIPK1CCNCCDK8GAAHPGD | |
| SCHEMBL4051349 | 0.76 | RIPK1 (0.44) | RIPK1CCNCCDK8GAAHPGD | |
| SCHEMBL28171621 | 0.76 | RIPK1 (0.67) | RIPK1SCD5PARP14PARP10EPHX2 | |
| SCHEMBL30878611 | 0.73 | RIPK1 (0.55) | RIPK1SCD5HSD17B10 | |
| SCHEMBL27564986 | 0.73 | RIPK1 (0.62) | RIPK1SCD5EPHX2 | |
| SCHEMBL1576663 | 0.72 | RIPK1 (0.73) | RIPK1SCD5EPHX2 | |
| SCHEMBL28916713 | 0.70 | RIPK1 (0.48) | RIPK1ROCK2HSD17B10GAAHPGD | |
| SCHEMBL2576253 | 0.70 | MLYCD (0.50) | MLYCDGPR119HPGD | |
| SCHEMBL5458875 | 0.69 | NPC1 (0.48) | RIPK1HSD17B10GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103478-A1 | PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |