Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.44 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046232 | 0.84 | RIPK1 (0.51) | RIPK1CCNCCDK8GAAHPGD | |
| SCHEMBL4046089 | 0.83 | RIPK1 (0.50) | RIPK1CCNCCDK8GAAHPGD | |
| SCHEMBL28171621 | 0.80 | RIPK1 (0.67) | RIPK1PARP14PARP10HSD11B1 | |
| SCHEMBL30878611 | 0.77 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL26985051 | 0.77 | NPC1 (0.47) | RIPK1 | |
| SCHEMBL27564986 | 0.76 | RIPK1 (0.62) | RIPK1HSD11B1 | |
| SCHEMBL4046460 | 0.76 | MLYCD (0.44) | RIPK1CCNCCDK8GAAHPGD | |
| SCHEMBL1576663 | 0.76 | RIPK1 (0.73) | RIPK1HSD11B1 | |
| SCHEMBL7518589 | 0.75 | GSK3B (0.45) | RIPK1GSK3BPTPN1PARP10 | |
| SCHEMBL1576492 | 0.72 | RIPK1 (0.49) | RIPK1CCNCCDK8HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103478-A1 | PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |