Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.51 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | CFB | P00751 | 5/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046089 | 0.88 | RIPK1 (0.50) | RIPK1CCNCCDK8GAAHPGD | |
| SCHEMBL28171621 | 0.87 | RIPK1 (0.67) | RIPK1HSD11B1PARP14PARP10 | |
| SCHEMBL4051349 | 0.84 | RIPK1 (0.44) | RIPK1CCNCCDK8HSD11B1PARP14 | |
| SCHEMBL27564986 | 0.83 | RIPK1 (0.62) | RIPK1HSD11B1 | |
| SCHEMBL1576663 | 0.82 | RIPK1 (0.73) | RIPK1HSD11B1 | |
| SCHEMBL30878611 | 0.81 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL4046460 | 0.80 | MLYCD (0.44) | RIPK1CCNCCDK8CFBPARP14 | |
| SCHEMBL4967031 | 0.78 | RIPK1 (0.49) | RIPK1PDE5APARP14PARP10 | |
| SCHEMBL13180874 | 0.76 | RIPK1 (0.49) | RIPK1 | |
| SCHEMBL21962365 | 0.76 | RIPK1 (0.49) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103478-A1 | PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |