Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.31 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046851 | 0.94 | LMNA (0.34) | METAP2METAP1DRD2DRD4DRD3 | |
| SCHEMBL4047661 | 0.83 | PBK (0.42) | METAP2METAP1CCNB2CDK1CCNB1 | |
| SCHEMBL4040136 | 0.77 | AAK1 (0.43) | METAP2METAP1CCNB2CDK1CCNB1 | |
| SCHEMBL4052252 | 0.75 | KDM4C (0.41) | METAP2METAP1CCNB2CDK1CCNB1 | |
| SCHEMBL4047123 | 0.75 | METAP2 (0.36) | METAP2METAP1 | |
| SCHEMBL4051241 | 0.72 | PI4KA (0.45) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL4044144 | 0.72 | METAP2 (0.34) | METAP2METAP1 | |
| SCHEMBL4046923 | 0.71 | PI4KA (0.51) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL4046994 | 0.71 | ADORA1 (0.42) | METAP2METAP1CDK1CCNB1GSK3A | |
| SCHEMBL4053122 | 0.69 | GPR84 (0.47) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029592-A1 | HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |
| WO-2009029592-A1 | HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |