Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.31 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047123 | 0.90 | METAP2 (0.36) | METAP2METAP1 | |
| SCHEMBL4051241 | 0.78 | PI4KA (0.45) | PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL4046923 | 0.77 | PI4KA (0.51) | HCAR2PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL4053122 | 0.74 | GPR84 (0.47) | METAP2METAP1HCAR2PI4KAPI4K2B | |
| SCHEMBL4052252 | 0.74 | KDM4C (0.41) | METAP2METAP1PI4KAPI4K2BPI4K2A | |
| SCHEMBL4046849 | 0.72 | METAP2 (0.35) | METAP2METAP1 | |
| SCHEMBL4046172 | 0.72 | METAP2 (0.35) | METAP2METAP1 | |
| SCHEMBL4046851 | 0.70 | LMNA (0.34) | METAP2METAP1HCAR2 | |
| SCHEMBL13905292 | 0.70 | PDE9A (0.35) | METAP2METAP1 | |
| SCHEMBL4046994 | 0.70 | ADORA1 (0.42) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029592-A1 | HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |
| WO-2009029592-A1 | HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |