Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.55 |
| ▸ | THRA | P10827 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2153706 | 0.80 | L3MBTL1 (0.62) | GSK3BPTPN1THRATHRBL3MBTL1 | |
| SCHEMBL9520211 | 0.80 | THRB (0.54) | THRATHRBL3MBTL1ALDH1A1POLB | |
| SCHEMBL205280 | 0.80 | GSK3B (0.80) | GSK3BPTPN1RAB9A | |
| SCHEMBL10594828 | 0.79 | CNR2 (0.46) | THRATHRBALDH1A1MAPT | |
| SCHEMBL6816324 | 0.79 | GSK3B (0.64) | GSK3BPTPN1 | |
| SCHEMBL9237039 | 0.79 | GSK3B (0.64) | GSK3BPTPN1THRATHRBALDH1A1 | |
| SCHEMBL8773680 | 0.78 | FFAR1 (0.57) | GSK3BPTPN1L3MBTL1 | |
| SCHEMBL8611695 | 0.78 | CYP4A11 (0.56) | GSK3BPTPN1THRATHRBRAB9A | |
| SCHEMBL7605422 | 0.77 | GSK3B (0.53) | GSK3BPTPN1THRATHRB | |
| SCHEMBL13131233 | 0.77 | GSK3B (0.64) | GSK3BPTPN1THRATHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103478-A1 | PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | disclosed |
| US-6380187-B2 | FUNGICIDES | YU DINGWEI TIM (US) | 2002-04-30 | — | — | US | disclosed |
| US-20020002193-A1 | Thiadiazole antifungal agents | YU DINGWEI TIM (US) | 2002-01-03 | — | — | US | disclosed |
| US-6281217-B2 | ANTIFUNGAL ACTIVITY AGAINST A VARIETY OF FUNGI INCLUDING STRAINS WHICH HAVE PROVEN TO BE RESISTANT TO TREATMENT WITH KNOWN ANTIFUNGAL AGENTS SUCH AS FLUCONAZOLE. | YU DINGWEI TIM (US) | 2001-08-28 | — | — | US | disclosed |
| US-6277873-B1 | CONTROLLING DRUG RESISTANT FUNGI | YU DINGWEI TIM (US) | 2001-08-21 | — | — | US | disclosed |
| US-20010000512-A1 | Novel class of piperazino substituted thiazoles | YU DINGWEI TIM (US) | 2001-04-26 | — | — | US | disclosed |
| US-20010000177-A1 | Novel class of thiomorpholino substituted thiazoles | YU DINGWEI TIM (US) | 2001-04-05 | — | — | US | disclosed |
| US-20010000178-A1 | PYRIDYL SUBSTITUTED THIAZOLES | YU DINGWEI TIM (US) | 2001-04-05 | — | — | US | disclosed |
| US-6156776-A | Diaryl substituted thiazoles useful in the treatment of fungal infections | YU DINGWEI TIM (US) | 2000-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000177-A1 | Novel class of thiomorpholino substituted thiazoles | THUMPD1, ERG28, THOC2 | GSK3B 3907/4885PTPN1 2299/4885THRA 1145/4885 |
| US-20020002193-A1 | Thiadiazole antifungal agents | ERG28, NAT1, AADAC | GSK3B 2559/4885PTPN1 3814/4885THRA 2617/4885 |
| US-20010000512-A1 | Novel class of piperazino substituted thiazoles | ERG28, DPM1, NAT1 | GSK3B 3464/4885PTPN1 3591/4885THRA 2901/4885 |
| US-20010000178-A1 | PYRIDYL SUBSTITUTED THIAZOLES | PDXK, OXA1L, ERG28 | GSK3B 2247/4885PTPN1 1950/4885THRA 2873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.