Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 18/20 | 0.45 |
| ▸ | CTSL | P07711 | 16/20 | 0.45 |
| ▸ | CTSS | P25774 | 12/20 | 0.45 |
| ▸ | CTSB | P07858 | 4/20 | 0.45 |
| ▸ | CTSV | O60911 | 2/20 | 0.42 |
| ▸ | GRN | P28799 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045549 | 0.92 | CTSL (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4043689 | 0.91 | CTSK (0.51) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4053835 | 0.90 | CTSK (0.40) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4047618 | 0.90 | CTSK (0.40) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4039158 | 0.89 | CTSK (0.40) | CTSKCTSLCTSSCTSBGRN | |
| SCHEMBL4046622 | 0.87 | CTSK (0.40) | CTSKCTSLCTSSCTSBGRN | |
| SCHEMBL4046952 | 0.86 | CTSK (0.39) | CTSKCTSLCTSSCTSBGRN | |
| SCHEMBL4045238 | 0.86 | CTSK (0.42) | CTSKCTSLCTSSCTSBGRN | |
| SCHEMBL4045678 | 0.85 | CTSK (0.49) | CTSKCTSLCTSSCTSBGRN | |
| SCHEMBL4042621 | 0.85 | CTSK (0.45) | CTSKCTSLCTSSCTSBCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | claimed |
| EP-1189905-B1 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-09-29 | — | — | EP | claimed |
| EP-1189904-B1 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-09-22 | — | — | EP | claimed |