Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 15/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 15/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047654 | 1.00 | MTNR1A (0.51) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4049338 | 1.00 | MTNR1A (0.51) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL14177909 | 0.88 | MTNR1A (0.39) | MTNR1AMTNR1BKDM4EALDH1A1CYP1A2 | |
| SCHEMBL14177908 | 0.84 | MTNR1A (0.42) | MTNR1AMTNR1BKDM4EHPGDTSHR | |
| SCHEMBL5113466 | 0.80 | HTR1A (0.43) | KDM4EHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL5113470 | 0.80 | HTR1A (0.43) | KDM4EHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL4049451 | 0.79 | HTR6 (0.53) | MTNR1AKDM4EALDH1A1CYP1A2MAPT | |
| SCHEMBL3324374 | 0.79 | HTR6 (0.53) | MTNR1AKDM4EALDH1A1CYP1A2MAPT | |
| SCHEMBL4058308 | 0.79 | HTR6 (0.53) | MTNR1AKDM4EALDH1A1CYP1A2MAPT | |
| SCHEMBL4050271 | 0.73 | HTR6 (0.46) | KDM4EALDH1A1CYP1A2MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1704154-B1 | NOVEL INDENO [2,1A]INDENES AND ISOINDOL [2,1-A]INDOLES | SUVEN LIFE SCIENCES LTD (IN) | 2009-05-06 | — | — | EP | claimed |
| US-7388024-B2 | Indeno[2,1A]indenes and isoindolo[2,1-A]indoles | SUVEN LIFE SCIENCES LIMITED (IN) | 2008-06-17 | — | — | US | claimed |
| US-20070054946-A1 | Novel indeno[2,1A]indenes and isoindolo[2,1-A]indoles | SUVEN LIFE SCIENCES LIMITED (IN) | 2007-03-08 | — | — | US | claimed |
| EP-1704154-A1 | NOVEL INDENO [2,1A]INDENES AND ISOINDOL [2,1-A]INDOLES | Suven Life Sciences Limited (IN) | 2006-09-27 | — | — | EP | claimed |
| WO-2005066184-A1 | NOVEL INDENO[2,1A]INDENES AND ISOINDOL[2,1-A]INDOLES | SUVEN LIFE SCIENCES LIMITED (IN) | 2005-07-21 | — | — | WO | claimed |
| EP-1704154-B1 | NOVEL INDENO [2,1A]INDENES AND ISOINDOL [2,1-A]INDOLES | SUVEN LIFE SCIENCES LTD (IN) | 2009-05-06 | — | — | EP | disclosed |
| US-7388024-B2 | Indeno[2,1A]indenes and isoindolo[2,1-A]indoles | SUVEN LIFE SCIENCES LIMITED (IN) | 2008-06-17 | — | — | US | disclosed |
| US-20070054946-A1 | Novel indeno[2,1A]indenes and isoindolo[2,1-A]indoles | SUVEN LIFE SCIENCES LIMITED (IN) | 2007-03-08 | — | — | US | disclosed |
| EP-1704154-A1 | NOVEL INDENO [2,1A]INDENES AND ISOINDOL [2,1-A]INDOLES | Suven Life Sciences Limited (IN) | 2006-09-27 | — | — | EP | disclosed |
| WO-2005066184-A1 | NOVEL INDENO[2,1A]INDENES AND ISOINDOL[2,1-A]INDOLES | SUVEN LIFE SCIENCES LIMITED (IN) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054946-A1 | Novel indeno[2,1A]indenes and isoindolo[2,1-A]indoles | IDO1, IDO2, OPRD1 | MTNR1A 122/4885MTNR1B 126/4885KDM4E 1535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.