Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | MAP2 | P11137 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 7/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39858 | 0.87 | CNR2 (0.49) | CNR2MAP2KDM4EALDH1A1EGFR | |
| SCHEMBL45059 | 0.80 | PTGS2 (0.41) | CNR2MAP2KDM4EALDH1A1POLB | |
| SCHEMBL47298 | 0.80 | PTGS2 (0.41) | CNR2MAP2KDM4EALDH1A1POLB | |
| SCHEMBL39935 | 0.73 | ALDH1A1 (0.62) | CNR2MAP2KDM4EALDH1A1POLB | |
| SCHEMBL39923 | 0.73 | OPRK1 (0.45) | MAP2KDM4EALDH1A1EGFRCDK2 | |
| SCHEMBL39889 | 0.72 | MAP2 (0.69) | MAP2KDM4EALDH1A1POLBMAPT | |
| SCHEMBL39921 | 0.72 | CNR2 (0.50) | CNR2MAP2KDM4EALDH1A1EGFR | |
| SCHEMBL13151483 | 0.71 | ALDH1A1 (0.46) | MAP2KDM4EALDH1A1POLBMAPT | |
| SCHEMBL40494 | 0.70 | ALDH1A1 (0.72) | MAP2ALDH1A1MAPT | |
| SCHEMBL23709743 | 0.68 | ACHE (0.45) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028990-A1 | 3 ARYL OR HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE | MSD K.K | 2012-02-02 | — | — | US | claimed |
| US-20120028990-A1 | 3 ARYL OR HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE | MSD K.K | 2012-02-02 | — | — | US | disclosed |
| US-20120028990-A1 | 3 ARYL OR HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE | MSD K.K | 2012-02-02 | — | — | US | disclosed |
| WO-2010119984-A1 | 3-ARYL OR HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028990-A1 | 3 ARYL OR HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE | IDO1, TPH1, AHR | CNR2 53/4885MAP2 1030/4885KDM4E 2947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.