Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 4/20 | 0.52 |
| ▸ | ACHE | P22303 | 4/20 | 0.52 |
| ▸ | BACE1 | P56817 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094770 | 0.87 | ACHE (0.57) | SIGMAR1KMT2ABCHEACHEBACE1 | |
| SCHEMBL5102012 | 0.81 | SIGMAR1 (0.57) | SIGMAR1ALDH1A1POLBKMT2ABCHE | |
| SCHEMBL5871316 | 0.76 | KDM4E (0.69) | SIGMAR1ALDH1A1POLBKMT2ABCHE | |
| SCHEMBL16225922 | 0.74 | ALDH1A1 (0.74) | SIGMAR1ALDH1A1KMT2AGAA | |
| SCHEMBL8155639 | 0.74 | SIGMAR1 (0.63) | SIGMAR1ALDH1A1POLBKMT2ABCHE | |
| SCHEMBL16226357 | 0.74 | SLC6A3 (0.66) | SIGMAR1ALDH1A1BCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL7405619 | 0.73 | CCR3 (0.69) | SIGMAR1ALDH1A1KMT2AACHEKDM4E | |
| SCHEMBL5360595 | 0.72 | ALDH1A1 (0.62) | SIGMAR1ALDH1A1KMT2ABCHEACHE | |
| SCHEMBL8035649 | 0.72 | SIGMAR1 (1.00) | SIGMAR1CCR3 | |
| SCHEMBL12677054 | 0.72 | KMT2A (1.00) | SIGMAR1ALDH1A1POLBKMT2ACCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013214-B1 | CONSTRAINED COMPOUNDS AS CGRP-RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2015-06-24 | — | — | EP | disclosed |
| EP-2013214-A2 | CONSTRAINED COMPOUNDS AS CGRP-RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2009-01-14 | — | — | EP | disclosed |
| US-7470680-B2 | Constrained compounds as CGRP-receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-30 | — | — | US | disclosed |
| WO-2007131020-A2 | CONSTRAINED COMPOUNDS AS CGRP-RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-11-15 | — | — | WO | disclosed |
| US-20070259851-A1 | CONSTRAINED COMPOUNDS AS CGRP-RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259851-A1 | CONSTRAINED COMPOUNDS AS CGRP-RECEPTOR ANTAGONISTS | CALCR, BDKRB2, CALCRL | SIGMAR1 907/4885ALDH1A1 3451/4885POLB 3259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.