Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | CCR2 | P41597 | 3/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048631 | 0.94 | KMT2A (0.51) | KMT2AMEN1CCR2OPRM1OPRL1 | |
| SCHEMBL4054992 | 0.91 | CCR2 (0.59) | KMT2AMEN1CCR2OPRM1OPRL1 | |
| SCHEMBL206079 | 0.87 | OPRM1 (0.54) | OPRM1OPRL1EPHX2EPHX1 | |
| SCHEMBL4072325 | 0.85 | OPRM1 (0.52) | OPRM1OPRL1EPHX2EPHX1 | |
| SCHEMBL4048579 | 0.84 | KMT2A (0.47) | KMT2AMEN1CCR2OPRM1OPRL1 | |
| SCHEMBL4048586 | 0.84 | CCR2 (0.49) | KMT2AMEN1CCR2OPRM1OPRL1 | |
| SCHEMBL2976452 | 0.84 | MEN1 (0.46) | KMT2AMEN1OPRM1OPRL1RAB9A | |
| SCHEMBL4054571 | 0.84 | ACKR3 (0.49) | KMT2AMEN1MCHR1 | |
| SCHEMBL4049886 | 0.84 | MAPT (0.45) | KMT2AMEN1CCR2NPC1RAB9A | |
| SCHEMBL4052851 | 0.83 | KMT2A (0.48) | KMT2AMEN1OPRM1OPRL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476763-B2 | Oxo-substituted cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2009-01-13 | — | — | US | disclosed |