Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049689 | 0.91 | KMT2A (0.53) | CCR2KMT2AMEN1OPRM1OPRL1 | |
| SCHEMBL4056032 | 0.90 | CCR2 (0.46) | CCR2LMNAKMT2AMEN1OPRM1 | |
| SCHEMBL4048586 | 0.89 | CCR2 (0.49) | CCR2HPGDKMT2AMEN1POLB | |
| SCHEMBL206079 | 0.86 | OPRM1 (0.54) | OPRM1OPRL1SIGMAR1EPHX2 | |
| SCHEMBL2986952 | 0.85 | MEN1 (0.47) | CCR2LMNAKMT2AMEN1OPRM1 | |
| SCHEMBL4049886 | 0.85 | MAPT (0.45) | CCR2HPGDLMNAKMT2AMEN1 | |
| SCHEMBL4048631 | 0.85 | KMT2A (0.51) | CCR2KMT2AMEN1POLBOPRM1 | |
| SCHEMBL2989386 | 0.85 | LMNA (0.45) | CCR2HPGDLMNAPOLB | |
| SCHEMBL16143615 | 0.84 | ACKR3 (0.48) | LMNAKMT2AMEN1 | |
| SCHEMBL4045470 | 0.84 | ACKR3 (0.48) | LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476763-B2 | Oxo-substituted cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2009-01-13 | — | — | US | disclosed |