Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | STAT6 | P42226 | 5/20 | 0.37 |
| ▸ | STAT5A | P42229 | 3/20 | 0.37 |
| ▸ | STAT5B | P51692 | 2/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052986 | 0.91 | NPY5R (0.44) | POLBMAPK14MAPK9STAT6STAT5A | |
| SCHEMBL4050227 | 0.91 | STAT6 (0.41) | POLBSTAT6STAT5ASTAT5BNPY5R | |
| SCHEMBL4055537 | 0.90 | TRPV4 (0.41) | ALDH1A1POLBSTAT6STAT5ASTAT5B | |
| SCHEMBL4052494 | 0.89 | TRPV4 (0.42) | MAPK14MAPK9STAT6STAT5ASTAT5B | |
| SCHEMBL4050971 | 0.88 | STAT6 (0.37) | STAT6STAT5ASTAT5BNPY5R | |
| SCHEMBL4053906 | 0.88 | NPY5R (0.48) | LMNAPOLBMAPK14MAPK9STAT6 | |
| SCHEMBL4052860 | 0.87 | NPY5R (0.47) | POLBSTAT6STAT5ASTAT5BNPY5R | |
| SCHEMBL4056428 | 0.86 | STAT6 (0.38) | POLBSTAT6STAT5ASTAT5BNPY5R | |
| SCHEMBL4058747 | 0.85 | CCR1 (0.41) | STAT6STAT5ASTAT5BNPY5RTAS1R3 | |
| SCHEMBL4053892 | 0.85 | STAT6 (0.40) | POLBSTAT6STAT5ASTAT5BNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |