Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 5/20 | 0.37 |
| ▸ | STAT5A | P42229 | 3/20 | 0.37 |
| ▸ | STAT5B | P51692 | 2/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | VHL | P40337 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052453 | 0.93 | NPY5R (0.39) | STAT6STAT5ASTAT5BNPY5RCTSB | |
| SCHEMBL4052986 | 0.91 | NPY5R (0.44) | STAT6STAT5ASTAT5BNPY5RCTSB | |
| SCHEMBL4055537 | 0.89 | TRPV4 (0.41) | STAT6STAT5ASTAT5BNPY5RKDM4E | |
| SCHEMBL4051924 | 0.89 | TRPV4 (0.42) | STAT6STAT5ASTAT5BNPY5RCTSB | |
| SCHEMBL4050227 | 0.89 | STAT6 (0.41) | STAT6STAT5ASTAT5BNPY5RCCR8 | |
| SCHEMBL4049802 | 0.88 | L3MBTL1 (0.44) | STAT6STAT5ASTAT5BNPY5R | |
| SCHEMBL4053906 | 0.87 | NPY5R (0.48) | STAT6STAT5ASTAT5BNPY5RCCR8 | |
| SCHEMBL8007248 | 0.86 | NPY5R (0.35) | STAT6STAT5ASTAT5BNPY5RCTSB | |
| SCHEMBL4052860 | 0.86 | NPY5R (0.47) | STAT6STAT5ASTAT5BNPY5RCCR8 | |
| SCHEMBL4056428 | 0.86 | STAT6 (0.38) | STAT6STAT5ASTAT5BNPY5RCCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |