Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059484 | 0.88 | PSEN1 (0.41) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4050626 | 0.85 | PDE4A (0.39) | ALDH1A1SMN1; SMN2MAPTSIGMAR1HTT | |
| SCHEMBL4054967 | 0.77 | PDE4A (0.37) | ALDH1A1SMN1; SMN2MAPTNPSR1L3MBTL1 | |
| SCHEMBL4241620 | 0.76 | PSEN1 (0.35) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2868054 | 0.76 | MAPT (0.39) | ALDH1A1SMN1; SMN2MAPTPSEN1PSEN2 | |
| SCHEMBL4050217 | 0.75 | BACE1 (0.32) | ALDH1A1SMN1; SMN2MAPTSIGMAR1HTR1A | |
| SCHEMBL521209 | 0.73 | PDE4B (0.42) | KMT2A | |
| SCHEMBL6617848 | 0.72 | PDE4A (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6601490 | 0.72 | PDE4B (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13693820 | 0.71 | PDE4A (0.41) | ALDH1A1SMN1; SMN2HTTHTR2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |