Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375183 | 0.86 | KDM4E (0.37) | KDM4EHSD17B10MAPTALDH1A1RXFP1 | |
| SCHEMBL5022288 | 0.72 | KDM4E (0.49) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL5022810 | 0.68 | TDP1 (0.45) | KDM4EHSD17B10HPGDMAPTALDH1A1 | |
| SCHEMBL16673026 | 0.68 | POLB (0.50) | KDM4EHPGDTSHRALDH1A1KMT2A | |
| SCHEMBL4375180 | 0.68 | PSEN1 (0.38) | KDM4EHSD17B10HPGDMAPTTSHR | |
| SCHEMBL4541903 | 0.65 | MYLK (0.40) | KDM4EHPGDMAPTTSHREGFR | |
| SCHEMBL30293800 | 0.64 | EGFR (0.53) | KDM4EHSD17B10HPGDMAPTTSHR | |
| SCHEMBL1004258 | 0.64 | FABP4 (0.64) | KDM4EHPGDMAPTTSHRALDH1A1 | |
| SCHEMBL31367787 | 0.64 | FABP4 (0.64) | KDM4EHPGDMAPTTSHRALDH1A1 | |
| SCHEMBL5026697 | 0.63 | ALKBH5 (0.59) | KDM4EHSD17B10HPGDMAPTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |