Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3501 | 0.83 | SMN1; SMN2 (0.40) | NPC1HPGDRAB9ASMN1; SMN2MAPT | |
| Oxalic Acid SCHEMBL4054 | 0.77 | SLC6A4 (0.50) | SLC6A9SLC6A4 | |
| Hydrochloric Acid SCHEMBL3937 | 0.75 | SLC6A4 (0.52) | HPGDSMN1; SMN2SLC6A9ALDH1A1SLC6A4 | |
| SCHEMBL7318201 | 0.74 | SLC6A9 (0.60) | NPC1HPGDRAB9ASMN1; SMN2SLC6A9 | |
| SCHEMBL4740321 | 0.73 | SLC6A9 (0.57) | NPC1RAB9AMAPTSLC6A9ALDH1A1 | |
| SCHEMBL3802 | 0.72 | OPRM1 (0.48) | NPC1RAB9ASMN1; SMN2SLC6A9PPARG | |
| Oxalic Acid SCHEMBL3500 | 0.72 | MEN1 (0.50) | NPC1HPGDRAB9ASMN1; SMN2MAPT | |
| SCHEMBL10539 | 0.72 | SLC7A5 (0.52) | NPC1RAB9ASLC6A9PPARGPPARA | |
| SCHEMBL5143084 | 0.71 | SLC6A2 (0.50) | SLC6A4SLC6A3 | |
| SCHEMBL4660 | 0.71 | HTR1A (0.46) | NPC1RAB9ASLC6A9SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |