Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048550 | 0.87 | ADORA3 (0.33) | ADORA3ADORA2AADORA2BADORA1METAP2 | |
| SCHEMBL4048043 | 0.84 | METAP2 (0.37) | METAP2METAP1EGLN1 | |
| SCHEMBL4043723 | 0.79 | METAP2 (0.41) | ADORA3ADORA2AADORA2BADORA1METAP2 | |
| SCHEMBL4046285 | 0.77 | GPR84 (0.35) | METAP2METAP1KDM4ESMN1; SMN2 | |
| SCHEMBL4048086 | 0.76 | METAP2 (0.39) | METAP2METAP1EGLN1 | |
| SCHEMBL4047234 | 0.75 | GPR84 (0.43) | METAP2METAP1 | |
| SCHEMBL3951248 | 0.74 | ADORA3 (0.38) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL3948888 | 0.73 | ADORA3 (0.34) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL4052403 | 0.71 | METAP2 (0.36) | METAP2METAP1EGLN1 | |
| SCHEMBL13905132 | 0.71 | METAP2 (0.33) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029592-A1 | HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |