Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.82 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.82 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.73 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | PTGES | O14684 | 1/20 | 0.60 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465162 | 0.91 | PTGS1 (0.80) | PTGS1PTGS2AKR1C3AKR1C2LMNA | |
| SCHEMBL17946351 | 0.91 | AKR1C3 (0.78) | PTGS1PTGS2AKR1C3AKR1C2LMNA | |
| SCHEMBL5558584 | 0.90 | PTGS1 (0.79) | PTGS1PTGS2AKR1C3AKR1C2LMNA | |
| SCHEMBL2996680 | 0.90 | PTGS1 (1.00) | PTGS1PTGS2AKR1C3AKR1C2LMNA | |
| SCHEMBL2997297 | 0.90 | PTGS2 (0.79) | PTGS1PTGS2AKR1C3AKR1C2LMNA | |
| SCHEMBL2002601 | 0.88 | PTGS1 (0.75) | PTGS1PTGS2AKR1C3AKR1C2LMNA | |
| SCHEMBL3002228 | 0.87 | AKR1C3 (0.76) | PTGS1PTGS2AKR1C3AKR1C2LMNA | |
| SCHEMBL6026590 | 0.87 | PTGS1 (0.70) | PTGS1PTGS2AKR1C3AKR1C2LMNA | |
| SCHEMBL27768669 | 0.87 | AKR1C3 (0.78) | PTGS1PTGS2AKR1C3AKR1C2LMNA | |
| SCHEMBL2615154 | 0.86 | AKR1C3 (0.83) | PTGS1PTGS2AKR1C3AKR1C2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | PTGS1 7/4885PTGS2 4/4885AKR1C3 577/4885 |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | PTGS1 363/4885PTGS2 460/4885AKR1C3 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.