Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 2/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 4/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373471 | 0.85 | ATR (0.50) | TPH1ALOX5APFEN1ATRPIM1 | |
| SCHEMBL4371541 | 0.85 | TPH1 (0.48) | TPH1ATRPIM1CYP3A4CYP2D6 | |
| SCHEMBL4056867 | 0.84 | ALOX5AP (0.42) | ALOX5APFEN1ATRPIK3CAROCK2 | |
| SCHEMBL4057216 | 0.81 | IKBKB (0.48) | TPH1ATRROCK2VNN1 | |
| SCHEMBL4370900 | 0.81 | IKBKB (0.48) | TPH1ATRROCK2VNN1 | |
| SCHEMBL4050033 | 0.81 | TPH1 (0.53) | TPH1ATRPIM1CYP3A4CYP2D6 | |
| SCHEMBL3982420 | 0.81 | GPR119 (0.54) | ALOX5APFEN1 | |
| SCHEMBL4234932 | 0.80 | TPH1 (0.49) | TPH1ATRPIM1CYP3A4CYP2D6 | |
| SCHEMBL4379368 | 0.79 | TPH1 (0.44) | TPH1ATRPIM1CYP3A4CYP2D6 | |
| SCHEMBL4053316 | 0.79 | ATR (0.41) | ALOX5APFEN1ATRVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |