Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690766 | 0.88 | GPR119 (0.56) | ALOX5APFEN1GPR119CHEK2 | |
| SCHEMBL3982420 | 0.88 | GPR119 (0.54) | ALOX5APFEN1GPR119CHEK2MEN1 | |
| SCHEMBL4376173 | 0.85 | ATR (0.48) | ALOX5APFEN1GPR119ATRGABRA5 | |
| SCHEMBL4388608 | 0.84 | ATR (0.42) | GPR119ATRGABRA5ATXN2CHEK2 | |
| SCHEMBL4056100 | 0.84 | TPH1 (0.44) | ALOX5APFEN1ATRROCK2PIK3CA | |
| SCHEMBL4048867 | 0.80 | SPHK2 (0.44) | GPR119ATRGABRA5ROCK2 | |
| SCHEMBL4049899 | 0.80 | SPHK2 (0.44) | GPR119ATRGABRA5ROCK2 | |
| SCHEMBL4059326 | 0.80 | PARP15 (0.45) | GPR119ATRCHEK2 | |
| SCHEMBL4053316 | 0.79 | ATR (0.41) | ALOX5APFEN1ATR | |
| SCHEMBL4368582 | 0.78 | ATR (0.39) | GPR119ATRGABRA5JAK2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |