Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 2/20 | 0.48 |
| ▸ | ATR | Q13535 | 5/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373471 | 0.96 | ATR (0.50) | TPH1ATRTBK1PIM1GRIN2B | |
| SCHEMBL13690750 | 0.86 | GPR119 (0.49) | TPH1 | |
| SCHEMBL4050033 | 0.86 | TPH1 (0.53) | TPH1ATRPIM1GRIN2BCYP3A4 | |
| SCHEMBL4056100 | 0.85 | TPH1 (0.44) | TPH1ATRTBK1PIM1GRIN2B | |
| SCHEMBL4234932 | 0.84 | TPH1 (0.49) | TPH1ATRPIM1GRIN2BCYP3A4 | |
| SCHEMBL13690341 | 0.83 | GPR119 (0.49) | TPH1ATRTBK1 | |
| SCHEMBL4057216 | 0.82 | IKBKB (0.48) | TPH1ATRVNN1IKBKB | |
| SCHEMBL4370900 | 0.82 | IKBKB (0.48) | TPH1ATRVNN1IKBKB | |
| SCHEMBL4379368 | 0.82 | TPH1 (0.44) | TPH1ATRPIM1GRIN2BCYP3A4 | |
| SCHEMBL4388608 | 0.81 | ATR (0.42) | ATRHTR2BHDAC4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |