Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MYLK | Q15746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062341 | 0.88 | TRPM8 (0.41) | MAPTSMN1; SMN2ACHEBCHETRPM8 | |
| SCHEMBL4066189 | 0.77 | PPIA (0.41) | TSHRKMT2ANPSR1TRPM8 | |
| SCHEMBL3956339 | 0.72 | MAPT (0.41) | POLBNPC1MEN1KMT2AMAPT | |
| SCHEMBL4067787 | 0.72 | TRPM8 (0.58) | TSHRMEN1KMT2AHTTMAPK1 | |
| SCHEMBL4061392 | 0.71 | TRPM8 (0.39) | MAPTSMN1; SMN2ACHEBCHETRPM8 | |
| SCHEMBL8588050 | 0.70 | ACHE (0.36) | POLBNPC1LMNAMEN1KMT2A | |
| SCHEMBL3062557 | 0.70 | ATM (0.41) | POLBLMNAMAPTTP53SMN1; SMN2 | |
| SCHEMBL3062426 | 0.68 | ALDH1A1 (0.41) | NPC1LMNAMAPTSMN1; SMN2MYLK | |
| SCHEMBL6372301 | 0.65 | ATM (0.46) | TSHRPOLBLMNAMAPTSMN1; SMN2 | |
| SCHEMBL10587030 | 0.64 | KDM4E (0.48) | TSHRPOLBNPC1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082358-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2009-03-26 | — | — | US | claimed |
| WO-2009038812-A1 | CONDENSED PIPERIDINE DERIVATIVES USEFUL AS VANILLOID RECEPTOR LIGANDS | AMGEN INC. (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009038812-A1 | CONDENSED PIPERIDINE DERIVATIVES USEFUL AS VANILLOID RECEPTOR LIGANDS | AMGEN INC. (US) | 2009-03-26 | — | — | WO | disclosed |
| US-20090082358-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2009-03-26 | — | — | US | disclosed |
| US-20090082358-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2009-03-26 | — | — | US | disclosed |
| US-20090082358-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2009-03-26 | — | — | US | disclosed |
| US-20090056995-A1 | ADHESIVE SHEET, METAL-LAMINATED SHEET AND PRINTED WIRING BOARD | TOYO BOSEKI KABUSHIKI KASIHA (JP) | 2009-03-05 | — | — | US | disclosed |
| EP-0459809-B1 | Polyimidosiloxane resin and composition thereof and method of applying same | UBE INDUSTRIES (JP) | 1995-02-08 | — | — | EP | disclosed |
| US-5081196-A | Containing an acetylenically unsaturated monoamine compound | UBE INDUSTRIES, LTD. (JP) | 1992-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082358-A1 | Vanilloid receptor ligands and their use in treatments | TRPV1, TRPV3, TRPV2 | TSHR 883/4885POLB 2169/4885NPC1 2723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.