SCHEMBL4057730

SCHEMBL4057730

CC[Si](CC)(CC)OC(C(C(=O)O)=C(C)I)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.38
CYP3A4 P08684 1/20 0.38
PPARA Q07869 4/20 0.34
SMN1; SMN2 Q16637 4/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
PKM P14618 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
LMNA P02545 1/20 0.33
HTT P42858 1/20 0.33
HSD17B10 Q99714 1/20 0.33
GLS O94925 2/20 0.33
KMT2A Q03164 2/20 0.33
MMP8 P22894 1/20 0.33
MTNR1A P48039 1/20 0.33
MTNR1B P49286 1/20 0.33
POLB P06746 1/20 0.32
PPARG P37231 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4051324 0.80 ASAH1 (0.40) ALDH1A1SMN1; SMN2NPSR1LMNA
SCHEMBL4052383 0.79 ASAH1 (0.41) ALDH1A1SMN1; SMN2
SCHEMBL4049543 0.79 ASAH1 (0.41) ALDH1A1SMN1; SMN2
SCHEMBL13754063 0.75 ALDH1A1 (0.40) ALDH1A1CYP3A4PPARASMN1; SMN2CYP1A2
SCHEMBL4062325 0.74 PPARG (0.41) PPARAPPARG
SCHEMBL4057726 0.72 PPARA (0.40) ALDH1A1PPARASMN1; SMN2PKMLMNA
SCHEMBL4060299 0.72 PPARA (0.40) ALDH1A1PPARASMN1; SMN2PKMLMNA
SCHEMBL10824109 0.72 LMNA (0.37) ALDH1A1CYP3A4PPARASMN1; SMN2CYP1A2
SCHEMBL20496665 0.71 MEN1 (0.37) ALDH1A1CYP3A4LMNAKMT2A
SCHEMBL17589051 0.71 MEN1 (0.37) ALDH1A1CYP3A4LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009110655-A1 NOVEL BETA SUBSTITUTED MORITA-BAYLIS-HILLMAN DERIVATIVES SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION (KR) 2009-09-11 WO disclosed