Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | PKM | P14618 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 11/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | RARA | P10276 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3526172 | 0.90 | SETD2 (0.57) | RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13907634 | 0.86 | RAB9A (0.54) | RAB9ANPC1PKMMAPK1TP53 | |
| SCHEMBL5108972 | 0.82 | ALDH1A1 (0.61) | NPC1PKMMAPTALDH1A1KMT2A | |
| SCHEMBL3228174 | 0.82 | CXCR2 (0.55) | RAB9ANPC1TP53MAPTATM | |
| SCHEMBL21911828 | 0.82 | NPC1 (0.50) | RAB9ANPC1PKMTP53MAPT | |
| SCHEMBL4058489 | 0.81 | MAPT (0.49) | RAB9ANPC1MAPK1TP53MAPT | |
| SCHEMBL13907637 | 0.80 | RAB9A (0.69) | RAB9ANPC1PKMMAPK1TP53 | |
| SCHEMBL3959381 | 0.80 | RAB9A (0.69) | RAB9ANPC1PKMMAPK1TP53 | |
| SCHEMBL16566639 | 0.79 | THRB (0.51) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL2352480 | 0.78 | PKM (0.70) | RAB9ANPC1PKMMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |