Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058495 | 0.81 | RAB9A (0.61) | MAPTMAPK1TP53GAAALDH1A1 | |
| SCHEMBL789351 | 0.80 | MAPT (0.47) | MAPTMAPK1TP53GAAALDH1A1 | |
| SCHEMBL20836396 | 0.77 | MAPT (0.40) | MAPTMAPK1GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL26165625 | 0.76 | ALDH1A1 (0.54) | MAPTTP53GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL789720 | 0.75 | LGMN (0.44) | MAPTMAPK1TP53GAAALDH1A1 | |
| SCHEMBL7980595 | 0.74 | MAPT (0.62) | MAPTMAPK1TP53GAAALDH1A1 | |
| SCHEMBL17548072 | 0.74 | LGMN (0.43) | MAPTMAPK1TP53GAAALDH1A1 | |
| SCHEMBL17637634 | 0.74 | LGMN (0.43) | MAPTMAPK1TP53GAAALDH1A1 | |
| SCHEMBL138606 | 0.73 | LPL (0.47) | MAPTMAPK1TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL2083166 | 0.73 | CA1 (0.37) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |