Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11837441 | 0.94 | CYP2C9 (0.46) | CYP2D6HIF1ACYP2C9EPHX2MAPT | |
| SCHEMBL7866065 | 0.80 | TSHR (0.48) | CYP2D6HIF1ACYP2C9MAPTALDH1A1 | |
| SCHEMBL637766 | 0.80 | ESR1 (0.52) | CYP2D6HIF1ACYP2C9ALDH1A1HPGD | |
| SCHEMBL30927966 | 0.80 | TSHR (0.48) | CYP2D6HIF1ACYP2C9MAPTALDH1A1 | |
| SCHEMBL284962 | 0.80 | ESR1 (0.52) | CYP2D6HIF1ACYP2C9ALDH1A1HPGD | |
| SCHEMBL5172480 | 0.80 | ESR1 (0.52) | CYP2D6HIF1ACYP2C9ALDH1A1HPGD | |
| SCHEMBL262460 | 0.80 | MAPT (0.48) | CYP2D6HIF1ACYP2C9EPHX2MAPT | |
| SCHEMBL197251 | 0.79 | MAPT (0.52) | CYP2D6HIF1ACYP2C9MAPTALDH1A1 | |
| SCHEMBL21557850 | 0.79 | MAPT (0.52) | CYP2D6HIF1ACYP2C9MAPTALDH1A1 | |
| SCHEMBL4326795 | 0.79 | MAPT (0.52) | CYP2D6HIF1ACYP2C9MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1291417-B1 | NOVEL (R)-2-HYDROXY-3-PHENYLPROPIONATE (D-PHENYLLACTATE) DEHYDROGENASE AND GENE ENCODING THE SAME | MEIJI SEIKA KAISHA (JP) | 2007-02-21 | — | — | EP | claimed |
| CN-1254536-C | Novel(R)-2-hydroxy-3-phenylpropionate (D-phenyllactate) dehydrogenase and gene encoding the same | MEIJI SEIKA KAISHA (JP) | 2006-05-03 | — | — | CN | claimed |
| CN-102264360-A | Methods of preventing or reducing colon carcinogenesis | — | 2011-11-30 | — | — | CN | disclosed |
| EP-1380649-B1 | TRANSFORMANT PRODUCING PF1022 SUBSTANCE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND NOVEL BIOSYNTHESIS GENE | MEIJI SEIKA KAISHA (JP) | 2009-10-21 | — | — | EP | disclosed |
| US-7432102-B2 | Transformants producing substance pf1022 derivatives, methods for producing the same, and novel biosynthesis genes | MEIJI SEIKA KAISHA, LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| EP-1291417-B1 | NOVEL (R)-2-HYDROXY-3-PHENYLPROPIONATE (D-PHENYLLACTATE) DEHYDROGENASE AND GENE ENCODING THE SAME | MEIJI SEIKA KAISHA (JP) | 2007-02-21 | — | — | EP | disclosed |
| US-7109018-B1 | Transformant producing secondary metabolite modified with functional group and novel biosynthesis genes | MEIJI SEIKA KAISHA, LTD. (JP) | 2006-09-19 | — | — | US | disclosed |
| CN-1254536-C | Novel(R)-2-hydroxy-3-phenylpropionate (D-phenyllactate) dehydrogenase and gene encoding the same | MEIJI SEIKA KAISHA (JP) | 2006-05-03 | — | — | CN | disclosed |
| US-6916641-B2 | (R)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same | MEIJI SEIKA KAISHA, LTD. (JP) | 2005-07-12 | — | — | US | disclosed |
| US-20040214274-A1 | Transformants producing substance pf1022 derivatives, methods for producing the same, and novel biosynthesis genes | MEIJI SEIKA KAISHA, LTD. (JP) | 2004-10-28 | — | — | US | disclosed |
| EP-1380649-A1 | TRANSFORMANT PRODUCING PF1022 SUBSTANCE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND NOVEL BIOSYNTHESIS GENE | MEIJI SEIKA KAISHA LTD. (JP) | 2004-01-14 | — | — | EP | disclosed |
| CN-1437651-A | Novel(R)-2-hydroxy-3-phenylpropionate (D-phenyllactate) dehydrogenase and gene encoding the same | MEIJI SEIKA KAISHA (JP) | 2003-08-20 | — | — | CN | disclosed |
| CN-1113101-C | Process for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms | BAYER AG (DE) | 2003-07-02 | — | — | CN | disclosed |
| EP-1291417-A1 | NOVEL (R)-2-HYDROXY-3-PHENYLPROPIONATE (D-PHENYLLACTATE) DEHYDROGENASE AND GENE ENCODING THE SAME | MEIJI SEIKA KAISHA LTD. (JP) | 2003-03-12 | — | — | EP | disclosed |
| EP-1223215-A1 | TRANSFORMANT PRODUCING SECONDARY METABOLITE MODIFIED WITH FUNCTIONAL GROUP AND NOVEL BIOSYNTHESIS GENES | MEIJI SEIKA KAISHA LTD. (JP) | 2002-07-17 | — | — | EP | disclosed |
| US-6033879-A | Process for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms | BAYER AKTIENGESELLSCHAFT (DE) | 2000-03-07 | — | — | US | disclosed |
| CN-1208439-A | Process for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms | BAYER AG (DE) | 1999-02-17 | — | — | CN | disclosed |
| EP-0816316-A1 | PROCESS FOR PRODUCING 1,2-ETHANEDIOL DERIVATIVES | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1998-01-07 | — | — | EP | disclosed |
| EP-0153763-A2 | Affinity chromatography matrix with built-in reaction indicator | J.T. Baker Inc. (US) | 1985-09-04 | — | — | EP | disclosed |
| US-4523997-A | Affinity chromatography matrix with built-in reaction indicator | J. T. BAKER CHEMICAL COMPANY (US) | 1985-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214274-A1 | Transformants producing substance pf1022 derivatives, methods for producing the same, and novel biosynthesis genes | GFPT1, FDPS, PSAT1 | CYP2D6 628/4885HIF1A 2336/4885CYP2C9 669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.