Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL406279 | 0.92 | KMT2A (0.41) | TEAD3CCNE1CDK2GSK3BALOX12 | |
| SCHEMBL11323517 | 0.84 | ALDH1A1 (0.47) | CCNE1CDK2GSK3BMEN1KMT2A | |
| SCHEMBL142445 | 0.84 | ALDH1A1 (0.47) | CCNE1CDK2GSK3BMEN1KMT2A | |
| SCHEMBL1279658 | 0.83 | ALDH1A1 (0.46) | CCNE1CDK2GSK3BMEN1KMT2A | |
| SCHEMBL17256401 | 0.83 | TEAD3 (0.43) | NAAATEAD3ALOX12MEN1GAA | |
| SCHEMBL6168143 | 0.82 | HCAR2 (0.45) | ALOX12PKMALDH1A1CYP3A4TSHR | |
| SCHEMBL11527408 | 0.82 | HTT (0.54) | CCNE1CDK2GSK3BMEN1GAA | |
| SCHEMBL13606692 | 0.81 | ALOX12 (0.32) | ALOX12SMN1; SMN2 | |
| SCHEMBL3230002 | 0.81 | NAAA (0.52) | NAAATEAD3KMT2AEPHX2ALDH1A1 | |
| SCHEMBL4702445 | 0.81 | TDP1 (0.57) | ALOX12KMT2AALDH1A1BCHEMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065152-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2012-03-15 | — | — | US | disclosed |
| EP-0528661-A2 | HIV protease inhibitors with N-terminal polyether substituents | MERCK & CO. INC. (US) | 1993-02-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065152-A1 | PRODRUGS OF GUANFACINE | UGT1A6, GDA, UGT1A3 | NAAA 259/4885TEAD3 3300/4885CCNE1 3273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.