Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 5/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 10/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059048 | 0.85 | EGLN1 (0.41) | EGLN3EGLN1MEN1KMT2ARXFP1 | |
| SCHEMBL2926999 | 0.69 | MEN1 (0.50) | EGLN3EGLN1MEN1KMT2ARXFP1 | |
| SCHEMBL4075882 | 0.67 | EGLN1 (0.48) | EGLN3EGLN1BBOX1ASPHKDM8 | |
| SCHEMBL5309940 | 0.65 | MEN1 (0.49) | EGLN3EGLN1MEN1KMT2ARXFP1 | |
| SCHEMBL4058167 | 0.65 | EGLN1 (0.39) | EGLN1BBOX1ASPHKDM8 | |
| SCHEMBL4158040 | 0.65 | MEN1 (0.46) | EGLN3EGLN1MEN1KMT2ARXFP1 | |
| SCHEMBL2929993 | 0.64 | MEN1 (0.50) | EGLN3EGLN1MEN1KMT2ARXFP1 | |
| SCHEMBL5309948 | 0.63 | MEN1 (0.61) | EGLN1MEN1KMT2ARXFP1NPC1 | |
| SCHEMBL4065499 | 0.63 | RPA1 (0.58) | EGLN3EGLN1MEN1KMT2ANPC1 | |
| SCHEMBL5308672 | 0.63 | MEN1 (0.47) | EGLN3EGLN1MEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009039323-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | claimed |
| WO-2009039323-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009039323-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |