Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069187 | 0.85 | CCRL2 (0.33) | DDR1TACR1 | |
| SCHEMBL5500736 | 0.81 | KMT2A (0.35) | OPRM1 | |
| SCHEMBL5499828 | 0.79 | DPP4 (0.38) | OPRM1 | |
| SCHEMBL5503146 | 0.74 | HTR2C (0.38) | OPRM1SLC6A4 | |
| SCHEMBL210897 | 0.74 | HSD11B1 (0.49) | EPHX2MCHR1ADRA2ANPY5ROPRM1 | |
| SCHEMBL5506343 | 0.73 | P2RX7 (0.46) | NPY5R | |
| SCHEMBL5241644 | 0.72 | NPY5R (0.34) | KCNH2NPY5RHCRTR1HCRTR2 | |
| SCHEMBL5508747 | 0.70 | CHRNB2 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL5503413 | 0.70 | DPP4 (0.36) | KCNH2OPRM1 | |
| SCHEMBL5503988 | 0.70 | P2RX7 (0.45) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541747-B | Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1 | LILLY CO ELI | 2012-11-14 | — | — | CN | disclosed |
| CN-101541747-A | Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1 | LILLY CO ELI (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2016047-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007124337-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |