Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | PNLIP | P16233 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065194 | 0.93 | ALDH1A1 (0.58) | ALDH1A1RAB9APNLIPKDM4ELMNA | |
| SCHEMBL4067700 | 0.91 | ALDH1A1 (0.50) | ALDH1A1RAB9APNLIPTP53KDM4E | |
| SCHEMBL4072610 | 0.88 | TYK2 (0.42) | ALDH1A1RAB9ATP53MAPTNPC1 | |
| SCHEMBL4069795 | 0.85 | ALDH1A1 (0.43) | ALDH1A1TP53KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL4061920 | 0.83 | ALDH1A1 (0.60) | ALDH1A1RAB9APNLIPKDM4ELMNA | |
| SCHEMBL4065181 | 0.80 | GRM4 (0.57) | PNLIPTP53KMT2AMEN1GRM4 | |
| SCHEMBL4070607 | 0.79 | RAB9A (0.41) | ALDH1A1RAB9ATP53KDM4EMAPT | |
| SCHEMBL4071750 | 0.74 | PNLIP (0.55) | PNLIPTP53GRM4 | |
| SCHEMBL4069792 | 0.74 | GRM8 (0.53) | ALDH1A1RAB9APNLIPKDM4ENPC1 | |
| SCHEMBL4068452 | 0.73 | CYP3A4 (0.44) | ALDH1A1KDM4EMAPTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |