Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.53 |
| ▸ | PNLIP | P16233 | 1/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064583 | 0.93 | ALDH1A1 (0.49) | ALDH1A1KCNMA1PNLIPGRM4NPC1 | |
| SCHEMBL4061920 | 0.90 | ALDH1A1 (0.60) | ALDH1A1KCNMA1PNLIPGRM4NPC1 | |
| SCHEMBL4069795 | 0.88 | ALDH1A1 (0.43) | ALDH1A1KDM4ESCN9AMEN1KMT2A | |
| SCHEMBL4072610 | 0.85 | TYK2 (0.42) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4067700 | 0.83 | ALDH1A1 (0.50) | ALDH1A1KCNMA1PNLIPGRM4NPC1 | |
| SCHEMBL4062244 | 0.80 | PNLIP (0.60) | ALDH1A1PNLIPGRM4NPC1RAB9A | |
| SCHEMBL4070607 | 0.75 | RAB9A (0.41) | ALDH1A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL4069792 | 0.75 | GRM8 (0.53) | ALDH1A1PNLIPGRM4NPC1RAB9A | |
| SCHEMBL4061271 | 0.74 | PNLIP (0.58) | ALDH1A1KCNMA1PNLIPGRM4NPC1 | |
| SCHEMBL4068452 | 0.74 | CYP3A4 (0.44) | ALDH1A1KDM4ESCN9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |