Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069795 | 0.93 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MRGPRX4MEN1POLB | |
| SCHEMBL4070607 | 0.90 | RAB9A (0.41) | TYK2JAK2RAB9AALDH1A1NPC1 | |
| SCHEMBL4064583 | 0.88 | ALDH1A1 (0.49) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL4065194 | 0.85 | ALDH1A1 (0.58) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL4061218 | 0.82 | GRM8 (0.43) | TYK2JAK2RAB9AALDH1A1NPC1 | |
| SCHEMBL4061697 | 0.80 | GRM8 (0.55) | TYK2JAK2JAK1POLB | |
| SCHEMBL4067700 | 0.79 | ALDH1A1 (0.50) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL4061920 | 0.75 | ALDH1A1 (0.60) | RAB9AALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL4066166 | 0.74 | ABL1 (0.48) | TYK2JAK2JAK1 | |
| SCHEMBL4068452 | 0.74 | CYP3A4 (0.44) | ALDH1A1SMN1; SMN2MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |