Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 12/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 12/20 | 0.60 |
| ▸ | GSK3A | P49840 | 12/20 | 0.60 |
| ▸ | GSK3B | P49841 | 12/20 | 0.60 |
| ▸ | CDK1 | P06493 | 9/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 8/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 8/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.60 |
| ▸ | AURKC | Q9UQB9 | 5/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.60 |
| ▸ | FLT3 | P36888 | 3/20 | 0.60 |
| ▸ | AURKA | O14965 | 3/20 | 0.60 |
| ▸ | SGK1 | O00141 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.60 |
| ▸ | GMNN | O75496 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | STK17B | O94768 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7915056 | 0.78 | MEN1 (0.65) | GSK3BCDK1MEN1NPC1USP2 | |
| SCHEMBL7915055 | 0.78 | MEN1 (0.65) | GSK3BCDK1MEN1NPC1USP2 | |
| SCHEMBL19400880 | 0.77 | ESR1 (0.50) | MEN1USP2ALDH1A1LMNAMAPT | |
| SCHEMBL21420134 | 0.75 | CDK5 (0.54) | CDK5CDK5R1GSK3AGSK3BCDK1 | |
| Indirubin-3-Monoxime SCHEMBL29354191 | 0.75 | CDK5R1 (1.00) | CDK5CDK5R1GSK3AGSK3BCDK1 | |
| SCHEMBL29924508 | 0.74 | GSK3B (0.72) | CDK5CDK5R1GSK3AGSK3BCDK1 | |
| SCHEMBL11174102 | 0.74 | AHR (0.55) | CDK5CDK5R1GSK3AGSK3BCDK1 | |
| SCHEMBL18787054 | 0.73 | ESR1 (0.87) | MEN1ALDH1A1MAPTTSHRKMT2A | |
| SCHEMBL18117823 | 0.72 | GSK3B (0.50) | CDK5CDK5R1GSK3AGSK3BCDK1 | |
| SCHEMBL3864662 | 0.71 | ESR1 (1.00) | ALDH1A1ESR1ESR2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4380629-A | Styryl-like compounds showing a color-developing and bleaching behavior with improved stability and prolonged lifetime | MATSUSHITA ELECTRIC INDUSTRIAL COMPANY, LIMITED (JP) | 1983-04-19 | — | — | US | claimed |
| US-4314058-A | Indolins styryl-like compounds | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1982-02-02 | — | — | US | claimed |
| US-4147862-A | Method of preparing styryl-like compounds | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1979-04-03 | — | — | US | claimed |
| CN-108218761-A | A kind of preparation method of 3- nitroso -2- phenyl -1H- indoles | 爱斯特（成都）生物制药股份有限公司 | 2018-06-29 | — | — | CN | disclosed |
| CN-108218761-A | A kind of preparation method of 3- nitroso -2- phenyl -1H- indoles | 爱斯特（成都）生物制药股份有限公司 | 2018-06-29 | — | — | CN | disclosed |
| EP-2033645-A1 | Isoquinoline derivatives and methods of use thereof | Inotek Pharmaceuticals Corporation (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-2033645-A1 | Isoquinoline derivatives and methods of use thereof | Inotek Pharmaceuticals Corporation (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1603568-A4 | ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORP (US) | 2009-02-25 | — | — | EP | disclosed |
| US-20080262016-A1 | ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2008-10-23 | — | — | US | disclosed |
| US-20080262016-A1 | ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2008-10-23 | — | — | US | disclosed |
| US-20080262016-A1 | ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2008-10-23 | — | — | US | disclosed |
| US-5858571-A | TREATING A PULVERIZED HYDROGEN ABSORBING ALLOY WITH A SOLUTION COMPRISING A CONJUGATED UNSATURATED COMPOUND | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1999-01-12 | — | — | US | disclosed |
| EP-0872903-A1 | Method for making hydrogen storage alloy powder and electrode comprising the alloy powder | Shin-Etsu Chemical Co., Ltd. (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0172427-B1 | PROCESS FOR PRODUCTION OF VINYL CHLORIDE POLYMER | Shin-Etsu Chemical Co., Ltd. (JP) | 1989-07-05 | — | — | EP | disclosed |
| US-4758639-A | Process for production of vinyl polymer | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1988-07-19 | — | — | US | disclosed |
| US-4757124-A | Suspension or emulsion polymerizing vinyl chloride monomer or mixture of vinyl chloride with vinyl monomer copolymerizable therewith in reactor with walls coated with antiscaling compound containing dye or pigments | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0172427-A2 | Process for production of vinyl chloride polymer | Shin-Etsu Chemical Co., Ltd. (JP) | 1986-02-26 | — | — | EP | disclosed |
| US-4380629-A | Styryl-like compounds showing a color-developing and bleaching behavior with improved stability and prolonged lifetime | MATSUSHITA ELECTRIC INDUSTRIAL COMPANY, LIMITED (JP) | 1983-04-19 | — | — | US | disclosed |
| US-4340624-A | STYRYL-LIKE COMPOUNDS | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1982-07-20 | — | — | US | disclosed |
| US-4003633-A | Color display device | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JA) | 1977-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262016-A1 | ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF | CYP3A7, CYP3A5, ABCG2 | CDK5 635/4885CDK5R1 1410/4885GSK3A 764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.