Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.30 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.30 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.30 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.30 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.30 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.30 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4241674 | 0.82 | — | — | |
| SCHEMBL5507890 | 0.81 | SLC6A3 (0.31) | SLC6A3APP | |
| SCHEMBL210558 | 0.76 | CNR2 (0.43) | ALDH1A1P2RX7 | |
| SCHEMBL208946 | 0.75 | P2RX7 (0.38) | ALDH1A1P2RX7 | |
| SCHEMBL209307 | 0.74 | PDE4D (0.41) | SLC6A3ALDH1A1 | |
| SCHEMBL3002602 | 0.73 | LDHA (0.36) | — | |
| SCHEMBL4070181 | 0.73 | SLC6A3 (0.33) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL2988655 | 0.72 | PDE4D (0.38) | SLC6A3ALDH1A1 | |
| SCHEMBL3001203 | 0.72 | FFAR4 (0.43) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL2993023 | 0.71 | PDE4D (0.37) | SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016047-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007124337-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |