Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511643 | 0.89 | FBP1 (0.34) | SLC6A3CYP3A4 | |
| SCHEMBL4065131 | 0.81 | SLC6A3 (0.33) | SLC6A3APP | |
| SCHEMBL3004306 | 0.78 | PPARA (0.39) | SLC6A3CYP3A4CYP2C9 | |
| SCHEMBL4241674 | 0.73 | — | — | |
| SCHEMBL3001203 | 0.68 | FFAR4 (0.43) | CYP2C9 | |
| SCHEMBL5507886 | 0.68 | HSD11B1 (0.50) | — | |
| SCHEMBL2990531 | 0.68 | LIPC (0.38) | SLC6A3 | |
| SCHEMBL4070181 | 0.67 | SLC6A3 (0.33) | SLC6A3 | |
| SCHEMBL2993665 | 0.67 | PPARA (0.43) | SLC6A3CYP3A4CYP2C9 | |
| SCHEMBL209307 | 0.66 | PDE4D (0.41) | SLC6A3CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |