Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL208914 | 0.75 | PGR (0.37) | — | |
| SCHEMBL2998442 | 0.75 | PGR (0.37) | SLC6A3 | |
| SCHEMBL4065131 | 0.73 | SLC6A3 (0.33) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL3543018 | 0.70 | PRMT5 (0.39) | SLC6A3GRM2 | |
| SCHEMBL3550340 | 0.70 | PTGS2 (0.35) | SLC6A3 | |
| SCHEMBL3547821 | 0.70 | BACE1 (0.40) | — | |
| Hydrochloric Acid SCHEMBL3549200 | 0.69 | BACE1 (0.40) | — | |
| SCHEMBL5507890 | 0.67 | SLC6A3 (0.31) | SLC6A3 | |
| SCHEMBL209307 | 0.67 | PDE4D (0.41) | SLC6A3 | |
| SCHEMBL208546 | 0.67 | PARP10 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016047-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007124337-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |