Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.68 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3985477 | 0.95 | ELANE (0.62) | ELANEKDM1ARAB9ANPC1RECQL | |
| SCHEMBL9341912 | 0.90 | ELANE (0.57) | ELANEKDM1ARAB9ANPC1RECQL | |
| SCHEMBL4061370 | 0.90 | ELANE (0.81) | ELANEKDM1ARAB9AMEN1KMT2A | |
| SCHEMBL4058207 | 0.87 | ELANE (0.54) | ELANEKDM1ARAB9ANPC1RECQL | |
| SCHEMBL13845260 | 0.86 | MAOB (0.58) | ELANECA2CA1CA9 | |
| SCHEMBL4058745 | 0.84 | NCEH1 (0.58) | ELANEKDM1ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4059798 | 0.84 | ELANE (0.72) | ELANEKDM1ARAB9AMEN1KMT2A | |
| SCHEMBL7195555 | 0.82 | ELANE (0.70) | ELANEKDM1AMEN1KMT2ALMNA | |
| SCHEMBL4057059 | 0.82 | ELANE (0.70) | ELANEKDM1AMEN1KMT2AMAPT | |
| SCHEMBL57101 | 0.81 | MEN1 (0.50) | RAB9AMEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107835680-B | Novel selective 11-beta-hydroxysteroid dehydrogenase type 1 | 帝斯曼知识产权资产管理有限公司 | 2021-11-09 | — | — | CN | disclosed |
| US-10550097-B2 | Selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors | DSM IP ASSETS B.V. (NL) | 2020-02-04 | — | — | US | disclosed |
| EP-3324924-B1 | NOVEL SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | DSM IP ASSETS BV (NL) | 2019-08-21 | — | — | EP | disclosed |
| US-20180208576-A1 | NOVEL SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | DSM IP ASSETS B.V. (NL) | 2018-07-26 | — | — | US | disclosed |
| EP-3324924-A1 | NOVEL SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | DSM IP Assets B.V. (NL) | 2018-05-30 | — | — | EP | disclosed |
| CN-107835680-A | The novel beta hydroxysteroid dehydrogenase of 1 type of selectivity 11 | 帝斯曼知识产权资产管理有限公司 | 2018-03-23 | — | — | CN | disclosed |
| WO-2017012890-A1 | NOVEL SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | DSM IP ASSETS B.V. (NL) | 2017-01-26 | — | — | WO | disclosed |
| WO-2011023791-A2 | METHOD FOR PRODUCING ORGANOALUMINIUM COMPOUNDS AND USE THEREOF | LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) | 2011-03-03 | — | — | WO | disclosed |
| US-7534547-B2 | Optically active compound and photosensitive resin composition | OSAKA GAS COMPANY LIMITED (JP) | 2009-05-19 | — | — | US | disclosed |
| US-7534547-B2 | Optically active compound and photosensitive resin composition | OSAKA GAS COMPANY LIMITED (JP) | 2009-05-19 | — | — | US | disclosed |
| US-6921623-B2 | Active components and photosensitive resin composition containing the same | KRI, INC. (JP) | 2005-07-26 | — | — | US | disclosed |
| EP-1375463-A1 | OPTICALLY ACTIVE COMPOUND AND PHOTOSENSITIVE RESIN COMPOSITION | Kansai Research Institute, Inc. (JP) | 2004-01-02 | — | — | EP | disclosed |
| US-20030211421-A1 | Optically active compound and photosensitive resin composition | KRI, INC. (JP) | 2003-11-13 | — | — | US | disclosed |
| US-20030064320-A1 | Active components and photosensitive resin composition containing the same | KRI, INC. (JP) | 2003-04-03 | — | — | US | disclosed |
| EP-1265103-A1 | ACTIVE COMPONENTS AND PHOTOSENSITIVE RESIN COMPOSITIONS CONTAINING THE SAME | Kansai Research Institute, Inc. (JP) | 2002-12-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10550097-B2 | Selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors | HSD11B1, HSD17B1, HSD3B1 | ELANE 1496/4885KDM1A 1275/4885RAB9A 3008/4885 |
| US-20180208576-A1 | NOVEL SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | HSD11B1, HSD17B1, HSD3B1 | ELANE 1456/4885KDM1A 1099/4885RAB9A 3066/4885 |
| US-20030211421-A1 | Optically active compound and photosensitive resin composition | ARCN1, RAD51, PAM | ELANE 422/4885KDM1A 113/4885RAB9A 2005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.