Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2046536 | 0.88 | THRB (0.41) | THRBTSHRHPGD | |
| Chloromethane SCHEMBL8427833 | 0.86 | THRB (0.40) | THRBTSHRHPGD | |
| Hydrochloric Acid SCHEMBL7804778 | 0.86 | THRB (0.40) | THRBTSHRHPGD | |
| SCHEMBL28187784 | 0.79 | DGAT1 (0.33) | TSHRHPGD | |
| SCHEMBL27430398 | 0.78 | THRB (0.37) | THRBTSHRHPGD | |
| SCHEMBL14482040 | 0.78 | TSHR (0.36) | THRBTSHRHPGD | |
| SCHEMBL1683533 | 0.76 | HPGD (0.32) | THRBTSHRHPGD | |
| SCHEMBL4065764 | 0.75 | ALDH1A1 (0.49) | THRBTSHRHPGD | |
| SCHEMBL13729493 | 0.75 | ALDH1A1 (0.33) | TSHR | |
| Acrylic Acid Methyl Ester SCHEMBL28844449 | 0.74 | TSHR (0.37) | THRBTSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109441-A2 | POLYSILOXANE BLOCK COPOLYMERS | Ciba Holding Inc. (CH) | 2009-10-21 | — | — | EP | claimed |
| WO-2008095822-A2 | POLYSILOXANE BLOCK COPOLYMERS | CIBA HOLDING INC. (CH) | 2008-08-14 | — | — | WO | claimed |