Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31146056 | 0.85 | AKR1C2 (0.49) | PIM1KDM4EALDH1A1MAPTGAA | |
| SCHEMBL4066152 | 0.78 | ALDH1A1 (0.44) | PIM1KDM4EALDH1A1MAPTGAA | |
| SCHEMBL31145902 | 0.78 | TSHR (0.44) | PIM1KDM4EALDH1A1MAPTGAA | |
| SCHEMBL4067945 | 0.73 | HSD17B10 (0.61) | KDM4EALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL31145982 | 0.72 | GRIN2D (0.41) | PIM1KDM4EALDH1A1MAPTGAA | |
| SCHEMBL3107966 | 0.72 | ALDH1A1 (0.54) | KDM4EALDH1A1MAPTGAAMEN1 | |
| SCHEMBL14485203 | 0.71 | KDM4E (0.65) | PIM1KDM4EALDH1A1MAPTGAA | |
| SCHEMBL31146266 | 0.71 | KDM4E (0.65) | PIM1KDM4EALDH1A1MAPTGAA | |
| SCHEMBL5677293 | 0.71 | EGLN1 (0.40) | PIM1KDM4EALDH1A1MAPTGAA | |
| SCHEMBL5678790 | 0.70 | MAPK1 (0.61) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049118-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SmithKline Beecham Corporation (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008011551-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-24 | — | — | WO | disclosed |