Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065690 | 0.95 | BRD4 (0.39) | MRGPRX4GPR132BRD4GRM5ADRB2 | |
| SCHEMBL4064790 | 0.93 | MRGPRX4 (0.39) | MRGPRX4KDM4ETDP1MAPK1CYP1A2 | |
| SCHEMBL4072391 | 0.90 | MRGPRX4 (0.40) | MRGPRX4GPR132KDM4ECYP1A2CYP2C9 | |
| SCHEMBL4068088 | 0.90 | FYN (0.40) | MRGPRX4GPR132GRM5 | |
| SCHEMBL2973144 | 0.89 | HPGD (0.45) | MRGPRX4GPR132KDM4EMAPK1CYP1A2 | |
| SCHEMBL4073758 | 0.89 | MRGPRX4 (0.41) | MRGPRX4GPR132GRM5PTGER1HSD17B13 | |
| SCHEMBL4066415 | 0.85 | GPR132 (0.46) | GPR132MAPK1HPGDADRB2 | |
| SCHEMBL2966243 | 0.84 | KMT2A (0.43) | MRGPRX4GPR132MAPK1CYP1A2CYP2C9 | |
| SCHEMBL4068787 | 0.83 | MRGPRX4 (0.40) | MRGPRX4KDM4ECYP1A2CYP2C9HPGD | |
| SCHEMBL4072173 | 0.83 | ATM (0.40) | MRGPRX4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658289-B1 | 3-SUBSTITUTED IMIDAZOPYRIDINE-DERIVATIVES AS C-KIT INHIBITORS | OSI PHARM INC (US) | 2009-03-18 | — | — | EP | claimed |