Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068787 | 0.92 | MRGPRX4 (0.40) | MRGPRX4GRM5MAOBADRB2CYP19A1 | |
| SCHEMBL4073758 | 0.92 | MRGPRX4 (0.41) | MRGPRX4GPR132GRM5CYSLTR2CYSLTR1 | |
| SCHEMBL4066534 | 0.90 | MRGPRX4 (0.40) | MRGPRX4GPR132GRM5PTGER1ADRB2 | |
| SCHEMBL4068088 | 0.90 | FYN (0.40) | MRGPRX4GPR132GRM5MAOBPDK1 | |
| SCHEMBL4065690 | 0.89 | BRD4 (0.39) | MRGPRX4GPR132GRM5ADRB2FAAH | |
| SCHEMBL4066415 | 0.87 | GPR132 (0.46) | GPR132ADRB2FAAHCYP19A1CYP11B1 | |
| SCHEMBL2975969 | 0.87 | GPR132 (0.43) | MRGPRX4GPR132PTGER1MAOBCYP19A1 | |
| SCHEMBL4069211 | 0.84 | MRGPRX4 (0.41) | MRGPRX4GRM5MAOBADRB2CYP19A1 | |
| SCHEMBL4064790 | 0.83 | MRGPRX4 (0.39) | MRGPRX4GRM5ADRB2CYP19A1CYP11B1 | |
| SCHEMBL2969649 | 0.82 | MRGPRX4 (0.44) | MRGPRX4GPR132PTGER1CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658289-B1 | 3-SUBSTITUTED IMIDAZOPYRIDINE-DERIVATIVES AS C-KIT INHIBITORS | OSI PHARM INC (US) | 2009-03-18 | — | — | EP | claimed |