Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 6/20 | 0.39 |
| ▸ | PPARA | Q07869 | 6/20 | 0.39 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072391 | 0.92 | MRGPRX4 (0.40) | MRGPRX4CYP19A1CYP11B1CYP11B2GRM5 | |
| SCHEMBL4069211 | 0.91 | MRGPRX4 (0.41) | MRGPRX4CYP19A1CYP11B1CYP11B2PPARD | |
| SCHEMBL4064790 | 0.90 | MRGPRX4 (0.39) | MRGPRX4CYP19A1CYP11B1CYP11B2PPARD | |
| SCHEMBL4072173 | 0.89 | ATM (0.40) | MRGPRX4CYP19A1CYP11B1CYP11B2PPARD | |
| SCHEMBL2961360 | 0.87 | HPGD (0.44) | MRGPRX4CYP19A1CYP11B1CYP11B2MAOB | |
| SCHEMBL4061701 | 0.86 | SMN1; SMN2 (0.44) | CYP19A1CYP11B1CYP11B2ADRB2ALDH1A1 | |
| SCHEMBL4069255 | 0.86 | MCHR1 (0.42) | CYP19A1CYP11B1CYP11B2HPGDALDH1A1 | |
| SCHEMBL4065692 | 0.85 | KDR (0.43) | HPGDALDH1A1 | |
| SCHEMBL4066271 | 0.85 | SLC6A5 (0.38) | PPARDPPARAPPARGHPGDALDH1A1 | |
| SCHEMBL4061393 | 0.84 | EPHX2 (0.44) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658289-B1 | 3-SUBSTITUTED IMIDAZOPYRIDINE-DERIVATIVES AS C-KIT INHIBITORS | OSI PHARM INC (US) | 2009-03-18 | — | — | EP | claimed |