Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 7/20 | 0.39 |
| ▸ | PPARA | Q07869 | 7/20 | 0.39 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066534 | 0.93 | MRGPRX4 (0.40) | MRGPRX4KDM4ETDP1HPGDCYP1A2 | |
| SCHEMBL4068787 | 0.90 | MRGPRX4 (0.40) | MRGPRX4KDM4EPPARDPPARAPPARG | |
| SCHEMBL4072173 | 0.89 | ATM (0.40) | MRGPRX4PPARDPPARAPPARGHPGD | |
| SCHEMBL2970729 | 0.88 | HPGD (0.47) | MRGPRX4KDM4EHPGDCYP1A2CYP2C9 | |
| SCHEMBL4065690 | 0.88 | BRD4 (0.39) | MRGPRX4ADRB2PDE2AGRM5 | |
| SCHEMBL4069211 | 0.88 | MRGPRX4 (0.41) | MRGPRX4PPARDPPARAPPARGHPGD | |
| SCHEMBL4069255 | 0.86 | MCHR1 (0.42) | HPGDCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL4065692 | 0.86 | KDR (0.43) | HPGD | |
| SCHEMBL4066271 | 0.85 | SLC6A5 (0.38) | PPARDPPARAPPARGHPGD | |
| SCHEMBL4061393 | 0.84 | EPHX2 (0.44) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658289-B1 | 3-SUBSTITUTED IMIDAZOPYRIDINE-DERIVATIVES AS C-KIT INHIBITORS | OSI PHARM INC (US) | 2009-03-18 | — | — | EP | claimed |