Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PPID | Q08752 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065398 | 0.92 | MAPT (0.49) | MAPTNAMPTALDH1A1LMNAADORA1 | |
| SCHEMBL4063854 | 0.89 | MAPT (0.50) | MAPTNAMPTALDH1A1LMNAADORA1 | |
| SCHEMBL18840970 | 0.88 | MAPT (0.48) | MAPTNAMPTALDH1A1LMNAADORA1 | |
| SCHEMBL4068097 | 0.82 | CYP3A4 (0.44) | MAPTALDH1A1LMNARAB9AHTT | |
| SCHEMBL8697615 | 0.78 | ALDH1A1 (0.55) | MAPTALDH1A1LMNAADORA1RAB9A | |
| SCHEMBL4067626 | 0.75 | LMNA (0.55) | MAPTALDH1A1LMNARAB9AHTT | |
| SCHEMBL4066911 | 0.75 | ALDH1A1 (0.49) | MAPTALDH1A1LMNARAB9AKDM4E | |
| SCHEMBL18840973 | 0.75 | ALDH1A1 (0.48) | MAPTALDH1A1LMNAADORA1RAB9A | |
| SCHEMBL18840958 | 0.74 | ALDH1A1 (0.48) | MAPTALDH1A1LMNAADORA1RAB9A | |
| SCHEMBL4066908 | 0.74 | CYP3A4 (0.46) | MAPTALDH1A1LMNARAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033955-A1 | Urea derivatives of 1H-pyrazol-4-carboxylic acid with neutrophil chemotaxis inhibiting activity | Universita' Degli Studi Di Genova (IT) | 2009-03-11 | — | — | EP | claimed |
| EP-2033955-A1 | Urea derivatives of 1H-pyrazol-4-carboxylic acid with neutrophil chemotaxis inhibiting activity | Universita' Degli Studi Di Genova (IT) | 2009-03-11 | — | — | EP | disclosed |