Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068097 | 0.91 | CYP3A4 (0.44) | CYP3A4CYP2C19LMNAPAX8ALDH1A1 | |
| SCHEMBL4062720 | 0.91 | CYP3A4 (0.47) | CYP3A4CYP2C19LMNAPAX8ALDH1A1 | |
| SCHEMBL18840958 | 0.84 | ALDH1A1 (0.48) | CYP3A4CYP2C19LMNAPAX8ALDH1A1 | |
| SCHEMBL4067165 | 0.83 | MAPT (0.53) | CYP3A4CYP2C19LMNAPAX8ALDH1A1 | |
| SCHEMBL4065398 | 0.81 | MAPT (0.49) | CYP3A4CYP2C19LMNAPAX8ALDH1A1 | |
| SCHEMBL4067626 | 0.81 | LMNA (0.55) | CYP3A4CYP2C19LMNAPAX8ALDH1A1 | |
| SCHEMBL4062182 | 0.80 | PAX8 (0.54) | LMNAPAX8ALDH1A1KDM4EMAPT | |
| SCHEMBL4066911 | 0.79 | ALDH1A1 (0.49) | LMNAPAX8ALDH1A1KDM4EMAPT | |
| SCHEMBL4075047 | 0.77 | MAPT (0.53) | CYP3A4CYP2C19LMNAPAX8ALDH1A1 | |
| SCHEMBL4072652 | 0.76 | NPC1 (0.60) | LMNAALDH1A1KDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033955-A1 | Urea derivatives of 1H-pyrazol-4-carboxylic acid with neutrophil chemotaxis inhibiting activity | Universita' Degli Studi Di Genova (IT) | 2009-03-11 | — | — | EP | claimed |
| EP-2033955-A1 | Urea derivatives of 1H-pyrazol-4-carboxylic acid with neutrophil chemotaxis inhibiting activity | Universita' Degli Studi Di Genova (IT) | 2009-03-11 | — | — | EP | disclosed |