Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075047 | 0.92 | MAPT (0.53) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL4062182 | 0.88 | PAX8 (0.54) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4067626 | 0.84 | LMNA (0.55) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4066908 | 0.83 | CYP3A4 (0.46) | MAPTNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL31065210 | 0.81 | PAX8 (0.54) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4073990 | 0.81 | PAX8 (0.54) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL4065398 | 0.80 | MAPT (0.49) | MAPTKMT2ARAB9AHPGDLMNA | |
| SCHEMBL4066911 | 0.80 | ALDH1A1 (0.49) | MAPTTRPV1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL18840973 | 0.80 | ALDH1A1 (0.48) | MAPTKMT2ANPC1RAB9AHPGD | |
| SCHEMBL4063973 | 0.76 | LMNA (0.55) | MAPTKMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033955-A1 | Urea derivatives of 1H-pyrazol-4-carboxylic acid with neutrophil chemotaxis inhibiting activity | Universita' Degli Studi Di Genova (IT) | 2009-03-11 | — | — | EP | claimed |
| EP-2033955-A1 | Urea derivatives of 1H-pyrazol-4-carboxylic acid with neutrophil chemotaxis inhibiting activity | Universita' Degli Studi Di Genova (IT) | 2009-03-11 | — | — | EP | disclosed |